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Reviewer of the Month (2023)

In 2023, ANPC reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

A protocol for international consensus guideline development on the delineation of radiotherapy target volumes for nasopharyngeal carcinoma after induction chemotherapy

Previous delineation consensus guidelines do not accurately specify radiation therapy target volumes and dose levels based on response to ICT. A phase III randomized trial comparing the delineation of pre-chemotherapy volume with delineation of post-chemotherapy volume showed, with a median follow-up of 98.4 months, comparable survival results between the two groups (overall, progression-free, locoregional recurrence-free, and distant metastasis-free survival) with less xerostomia, decreased hearing and better quality of life in favor of post-chemotherapy volume. The aim of this study is to develop a consensus guideline towards harmonizing practices based on a literature review and expert opinion (through an online survey).

NPC Biomarkers

The purpose of this special series on NPC biomarkers is to present an overview of conventional biomarkers used in NPC detection and monitoring, as well as include several more recent “novel” approaches for study of NPC and EBV for biomarker discovery, which are expected to identify informative biomarkers for its early detection or new biomarkers having prognostic implications. Experts in the field have been invited to provide several papers in this special series of Annals of Nasopharynx Cancer on EBV markers, as well as host biomarkers, for NPC screening, diagnosis, and prognosis and to present new avenues for NPC biomarker discovery.

Precision Radiotherapy in Nasopharyngeal Carcinoma

This special series on “Precision Radiotherapy in Nasopharyngeal Carcinoma” was guest-edited by Dr. Wai-Tong Ng, Dr. Sophie (Shao Hui) Huang and Dr. Hai-Qiang Mai. Precision radiotherapy in NPC is a fast evolving field. The collection of articles in this special issue is a snapshot of current understanding and future direction of this topic.

Late Complications in the Management of Nasopharyngeal Cancer

In this issue of Annals of Nasopharynx Cancer, we present articles that are intended to discuss the long-term complications of major normal organs at risks following radiotherapy for NPC. This issue also provides the late complications of chemotherapeutic agents using concurrently with radiotherapy for NPC. Additionally, we provide an article about diet and nutrition for irradiated NPC patients who suffered from late radiation induced toxicities

Annals of Nasopharynx Cancer—message from the Editor-in-Chief

It is with immense pleasure that we launch the inaugural issue of Annals of Nasopharynx Cancer—a journal dedicated to the sharing of clinical and translational scientific research in nasopharynx cancer.Nasopharynx cancer is unique; and particularly relevant to the clinical and scientific community in this part of the world. Age-standardised rates of this disease in Southern and Eastern parts of Asia exceed 15 per 100,000 person years, which are at least 15-fold greater than populations from the rest of the world. The endemic form is also invariably associated with Epstein-barr virus (EBV), although the molecular processes driving subsequent tumorigenesis remain elusive. Over the years, such observations have driven the bases for several population genetics and risk-exposure studies.

Editor-in-Chief: Melvin Lee Kiang Chua, MBBS, FRCR, PhD

Melvin L.K. Chua is a Clinician-Scientist at the National Cancer Centre Singapore, and an Instructor with the Duke-NUS Graduate Medical School. His research is focused on discovery and translational cancer genomics, and the development of biomarker-directed clinical trials in nasopharynx and prostate cancers.Dr. Chua graduated from the Yong Loo Lin School of Medicine, National University Singapore in 2002. He obtained his Fellowship in Clinical Oncology from the Royal College of Radiologists, and his Doctorate from the University College London in 2013. He later completed post-graduate fellowships at the Mount Vernon Cancer Centre, UK, and the Princess Margaret Cancer Centre, Toronto. Of specific mention, Dr. Chua was part of the multi-member Canadian Prostate Cancer Gene Network (CPC-GENE); the lead site of the International Cancer Genomics Consortium (ICGC) for prostate cancer. The group has published in several high impact journals, including Lancet Oncology, Nature, Nature Genetics, and Nature Communications.

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Cover image "Sea" by Zhijing Xu

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Study Protocol

A protocol for international consensus guideline development on the delineation of radiotherapy target volumes for nasopharyngeal carcinoma after induction chemotherapy

Warren Bacorro, Nejla Fourati, Hela Hammami Turki, Ryan Anthony Agas, Omar Nouri, Lester Bryan Co, Audrey Larnaudie, Clevelinda Calma, Melvin L. K. Chua, Michael Benedict Mejia, Jamel Daoud

Annals of Nasopharynx Cancer

2023;

(30 November 2023)

PDF Full Text (2362) COI Form Open Access

Review Article

Classifying the tumor microenvironment to stratify nasopharyngeal carcinoma patients

Shang-Xin Liu, Ge-Xin Zhao, Ruo-Bin Lin, Mu-Sheng Zeng, Qian Zhong

Annals of Nasopharynx Cancer

2022;

(30 September 2022)

PDF Full Text (2108) Peer Review File COI Form Open Access

Review Article

Clinical utility of circulating tumor cells for real-time serial monitoring of nasopharyngeal carcinoma patients

Josephine Mun Yee Ko

Annals of Nasopharynx Cancer

2022;

(30 June 2022)

PDF Full Text (1422) COI Form Open Access

Review Article

Utility of Epstein-Barr virus (EBV) antibodies as screening markers for nasopharyngeal carcinoma: a narrative review

Sweta Sinha, Brittney L. Dickey, Anna E. Coghill

Annals of Nasopharynx Cancer

2022;

(30 June 2022)

PDF Full Text (5141) Reporting Checklist COI Form Open Access

Review Article

CpG methylation as epigenetic biomarkers for nasopharyngeal carcinoma diagnostics

Lili Li, Jianlian Xie, Brigette Ma, Anthony T. C. Chan, Qian Tao

Annals of Nasopharynx Cancer

2022;

(30 June 2022)

PDF Full Text (2102) COI Form Open Access

Review Article

Plasma Epstein-Barr virus DNA analysis for personalised management of nasopharyngeal carcinoma—current opportunities and challenges

Wai Kei Jacky Lam, Yuk Ming Dennis Lo

Annals of Nasopharynx Cancer

2022;

(30 March 2022)

PDF Full Text (2612) COI Form Open Access

Review Article

Epstein-Barr virus-based nasopharyngeal carcinoma population screening

Xia Yu, Honglin Chen, Mingfang Ji

Annals of Nasopharynx Cancer

2022;

(30 March 2022)

PDF Full Text (4547) COI Form Open Access

Review Article

Prognostic value of Epstein-Barr virus biomarkers for nasopharyngeal carcinoma staging and post-treatment surveillance

Jacob A. Miller, Benjamin A. Pinsky, Quynh-Thu Le

Annals of Nasopharynx Cancer

2022;

(30 March 2022)

PDF Full Text (2717) COI Form Open Access

Editorial

The etiology of nasopharyngeal carcinoma and challenges for its diagnosis and treatment monitoring

Maria Li Lung

Annals of Nasopharynx Cancer

2022;

(30 March 2022)

PDF Full Text (2159) COI Form Open Access

Review Article

Stereotactic radiation therapy for recurrent nasopharyngeal carcinoma

Yu-Jie Huang, Fu-Min Fang, Hui-Chun Chen, Hsuan-Chih Hsu

Annals of Nasopharynx Cancer

2021;

(30 June 2021)

PDF Full Text (3302) COI Form Open Access

Editorial

EBV and NPC carcinogenesis—an alternative viewpoint

Sharon Shuxian Poh, Joseph T. S. Wee

Annals of Nasopharynx Cancer

2021;

(30 June 2021)

PDF Full Text (2742) COI Form Open Access

Review Article

miRNA biomarkers for NPC diagnosis and prognosis

Mackenzie Fijardo, Pierre-Antoine Bissey, Kenneth W. Yip, Fei-Fei Liu

Annals of Nasopharynx Cancer

2021;

(30 June 2021)

PDF Full Text (2651) COI Form Open Access

Review Article

Biological opportunities for personalized radiotherapy of nasopharyngeal carcinoma

Li Lin, Yu-Pei Chen, Ying Sun

Annals of Nasopharynx Cancer

2021;

(14 May 2021)

PDF Full Text (2276) COI Form Open Access

Editorial

Precision radiotherapy in nasopharyngeal carcinoma

Wai Tong Ng, Shao Hui Huang, Hai Qiang Mai

Annals of Nasopharynx Cancer

2021;

(14 May 2021)

PDF Full Text (1912) COI Form Open Access

Case Report

Ectopic parathyroid adenoma in pyriform sinus: a case report and literature review

John Tran, Chady Sader

Annals of Nasopharynx Cancer

2020;

(30 December 2020)

PDF Full Text (2673) Reporting Checklist COI Form Open Access

Editorial

Introduction: late complications in the management of nasopharyngeal cancer

Imjai Chitapanarux

Annals of Nasopharynx Cancer

2020;

(30 December 2020)

PDF Full Text (2036) COI Form Open Access

Review Article

Managing hidden late complications in irradiated head and neck cancer patients using a practical integrative approach: a narrative review

Roy Vongtama, Hoda Hakimjavadi, Meena Makhijani

Annals of Nasopharynx Cancer

2020;

(06 November 2020)

PDF Full Text (2367) Reporting Checklist COI Form Open Access

Review Article

Treatment of nasopharyngeal carcinoma in unique scenarios

Xue-Song Sun, Yu-Jing Liang, Mei-Juan Luo, Lin-Quan Tang, Qiu-Yan Chen, Hai-Qiang Mai

Annals of Nasopharynx Cancer

2020;

(06 November 2020)

PDF Full Text (3427) COI Form Open Access

Original Article

Local radiotherapy combined with systemic therapy for metastatic nasopharyngeal carcinomas at diagnosis: experience from a tertiary academic center in the Philippines

Kelvin Ken L. Yu, Ryan Anthony F. Agas, J. C. Kennetth M. Jacinto, Lester Bryan A. Co, Luisa E. Jacomina, Eugene Richard T. Yap, Michael Benedict A. Mejia

Annals of Nasopharynx Cancer

2020;

(06 November 2020)

PDF Full Text (2817) Reporting Checklist Data Sharing Statement COI Form Open Access

Review Article

Narrative review: temporal lobe necrosis after radiotherapy for nasopharyngeal carcinoma

Pei-Jing Li, Yuan-Yuan Chen

Annals of Nasopharynx Cancer

2020;

(19 October 2020)

PDF Full Text (4324) Reporting Checklist COI Form Open Access

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Editorial

Nasopharyngeal carcinoma contouring guidelines—the first step in a thousand mile journey

Michael Benedict A. Mejia, Warren R. Bacorro, Paolo G. Sogono

Published online: 14 May 2018

PDF Full Text (9079) COI Form Open Access

Review Article

Proton/heavy ion therapy in salvage of locally recurrent nasopharyngeal carcinoma

Michael C. H. Lee, Wai Tong Ng

Published online: 30 June 2020

PDF Full Text (9028) COI Form Open Access

Review Article

Why we should give spatially fractionated radiation therapy (GRID) a second look—especially in nasopharyngeal carcinoma

Sharon S. Poh, Melvin L. K. Chua, Joseph T. S. Wee

Published online: 18 April 2018

PDF Full Text (5915) COI Form Open Access

Review Article

Utility of Epstein-Barr virus (EBV) antibodies as screening markers for nasopharyngeal carcinoma: a narrative review

Sweta Sinha, Brittney L. Dickey, Anna E. Coghill

Published online: 30 June 2022

PDF Full Text (5141) Reporting Checklist COI Form Open Access

Review Article

Adaptive radiotherapy for nasopharyngeal carcinoma

Jishi Li, Zhiyuan Xu, Avinash Pilar, Brian O’Sullivan, Shao Hui Huang

Published online: 31 March 2020

PDF Full Text (4936) COI Form Open Access

Review Article

Epstein-Barr virus-based nasopharyngeal carcinoma population screening

Xia Yu, Honglin Chen, Mingfang Ji

Published online: 30 March 2022

PDF Full Text (4547) COI Form Open Access

Review Article

Narrative review: temporal lobe necrosis after radiotherapy for nasopharyngeal carcinoma

Pei-Jing Li, Yuan-Yuan Chen

Published online: 19 October 2020

PDF Full Text (4324) Reporting Checklist COI Form Open Access

Review Article

Hypothyroidism after radiotherapy for nasopharyngeal carcinoma

Anussara Prayongrat, Chawalit Lertbutsayanukul

Published online: 30 June 2020

PDF Full Text (4238) COI Form Open Access

Foreword

Annals of Nasopharynx Cancer—message from the Editor-in-Chief

Melvin Lee Kiang Chua

Published online: 13 January 2017

PDF Full Text (4279) COI Form Open Access

Review Article

Somatostatin receptor imaging in nasopharyngeal cancer

Wen-Long Nei, Amit Jain, Fu-Qiang Wang, Lih Kin Khor, Joe Poh-Sheng Yeong, Shu-Ting Han, Kiattisa Sommat, Mei Kim Ang, Yoke Lim Soong, Kelvin S. H. Loke

Published online: 01 February 2018

PDF Full Text (4135) COI Form Open Access

Review Article